Notes on Genus: Blosnavirus
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| icosahedra |
Type member: Blotched snakehead virus
Contents
| Members of this Genus General Description Morphology Electron Micrograph Genome Genus Genomic Organization Genome Map Type Member Genomic Organization Curated Sequences |
General Description
The genus Blosnavirus (from the type member Blotched snakehead virus) is one of four genera in the family Birnaviridae and contains viruses isolated from fish. Compared with other genera, there is an extra protein cleaved from the polyprotein on segment A and the sequences are only distantly related.Morphology
Virions isometric (icosahedral), not enveloped, 60 nm in diameter, made of 260 units trimeric subunits.Genome
Bipartite double-stranded RNA of about 3.4 and 2.8 kb, probably with a genome-linked protein (VPg) at the 5'-terminus and no 3'-polyA tail.Genus Genomic Organization
Each segment encodes a large polyprotein that it is subsequently processed into the functional products and there is an additional, smaller ORF on the larger (A) segment. The two capsid proteins and a non-structural protein are encoded on segment A and an RNA-dependent RNA polymerase on segment B.Type Member Genomic Organization
Segment A (3.4 kb) encodes:- ORF1: VP5, 15 kDa protein of unknown function
- ORF2: 115 kDa, Polyprotein that is subsequently processed into:
- VP2, 52 kDa major outer capsid protein precursor that undergoes further truncation and cleavage
- X protein, 8 kDa of unknown function
- VP4, 25 kDa protease
- VP3, 31 kDa internal capsid protein