Notes on Genus: Leishmaniavirus

icosahedra

Type member: Leishmania RNA virus 1-1

Contents

Members of this Genus
General Description
Morphology
Electron Micrograph
Genome
Genus Genomic Organization
Genome Map
Type Member Genomic Organization
All Known Sequences
Curated Sequences

General Description

This genus contains those members of the family Totiviridae that infect protozoa and which have particles 33nm in diameter. The name is derived from the genus infected by the type member.

Morphology

Virions isometric, 33 nm in diameter.

Genome

Monopartite, linear, double stranded RNA of about 5200-5300 base pairs.

Genus Genomic Organization

The genome has two large, overlapping ORFs on the positive strand with a small 5'-proximal potential ORF identified in some isolates:
1. 4-8 kDatheoretical protein
2. 77-82 kDaCoat protein (gag)
3.   87-99 kDaPolymerase (pol): RNA-dependent RNA polymerase probably expressed as a fusion protein with gag, usually by a ribosomal frameshift

Type Member Genomic Organization

Three ORFs have been identified:
1. 8 kDatheoretical protein
2. 82 kDaCoat protein (gag)
3.   98 kDaPolymerase (pol): RNA-dependent RNA polymerase probably expressed as a 176 kDa fusion protein with gag by a +1 ribosomal frameshift