Notes on Genus: Rubulavirus
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| enveloped spheres |
Type member: Mumps virus
Contents
| Members of this Genus General Description Morphology Electron Micrograph Genome Genus Genomic Organization Genome Map Type Member Genomic Organization Curated Sequences |
General Description
The genus Rubulavirus is one of nine genera in the family Paramyxoviridae and contains viruses that have a hemagglutinin-neuraminidase attachment protein, translate protein V from a non-edited RNA transcript and do not produce a non-strutural protein C. It is named from Rubula inflans, the old name for mumps (caused by the type member).Morphology
Virions pleomorphic but usually spherical, enveloped, 150 nm in diameter or larger with spike-like projections.Genome
Monopartite single-stranded negative sense RNA of about 15 kb. There is no genome-linked protein (VPg) at the 5'-terminus nor a 3'-polyA tail.Genus Genomic Organization
There are 6 or 7 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:| 1 | N | 56-61 kDa | Coat protein (nucleocapsid) |
| 2 | P | 41-42 kDa | Phosphoprotein produced by RNA editing, creating a frame shift |
| 3 | V | 24-25 kDa | Produced from the unedited P transcript |
| 4 | M | 41-42 kDa | Matrix protein |
| 5 | F | 57-60 kDa | Fusion protein: glycosylated envelope protein |
| 6 | SH | 5-7 kDa | Small membrane protein (in some members only) |
| 7 | H | 62-66 kDa | Hemagglutinin-neuraminidase attachment protein |
| 8 | L | 256-257 kDa | Polymerase |
Type Member Genomic Organization
There are 7 transcriptional elements (mRNA species). Their major ORFs are listed here in their order on the template strand - i.e. from 3' to 5' with respect to the virion strand:| 1 | N | 61 kDa | Coat protein (nucleocapsid) |
| 2 | P | 42 kDa | Phosphoprotein produced by RNA editing, creating a frame shift |
| 3 | V | 24 kDa | Produced from the unedited P transcript |
| 4 | M | 42 kDa | Matrix protein |
| 5 | F | 59 kDa | Fusion protein: glycosylated envelope protein |
| 6 | SH | 7 kDa | Small membrane protein |
| 7 | H | 64 kDa | Hemagglutinin-neuraminidase attachment protein |
| 8 | L | 257 kDa | Polymerase |