Sequence of DPV Grapevine fleck virus

Grapevine fleck virus complete genome, isolate MT48, genomic RNA

ACC No: AJ309022

Dated: 2005-04-15 | Length: 7564 | CRC: -2034195342

                !!NA_SEQUENCE 1.0
ID   GFL309022  standard; genomic RNA; VRL; 7564 BP.
XX
AC   AJ309022;
XX
SV   AJ309022.1
XX
DT   04-JAN-2002 (Rel. 70, Created)
DT   15-APR-2005 (Rel. 83, Last updated, Version 3)
XX
DE   Grapevine fleck virus complete genome, isolate MT48, genomic RNA
XX
KW   coat protein; complete genome; cp gene; ORF3; ORF4; rep gene; replicase.
XX
OS   Grapevine fleck virus
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Tymoviridae;
OC   Maculavirus.
XX
RN   [1]
RP   1-7564
RA   Sabanadzovic S.;
RT   ;
RL   Submitted (29-MAR-2001) to the EMBL/GenBank/DDBJ databases.
RL   Sabanadzovic S., Plant Protection, Istituto Agronomico Mediterraneo, Via
RL   Ceglie 9, 70010 Valenzano (BA), ITALY.
XX
RN   [2]
RX   MEDLINE; 21351056.
RX   PUBMED; 11458008.
RA   Sabanadzovic S., Abou Ghanem-Sabanadzovic N., Saldarelli P., Martelli G.P.;
RT   "Complete nucleotide sequence and genome organisation of Grapevine fleck
RT   virus";
RL   J. Gen. Virol. 82(Pt 8):2009-2015(2001).
XX
FH   Key             Location/Qualifiers
FH
FT   source          1. .7564
FT                   /country="Italy"
FT                   /db_xref="taxon:103722"
FT                   /mol_type="genomic RNA"
FT                   /virion
FT                   /organism="Grapevine fleck virus"
FT                   /isolate="MT48"
FT   5'UTR           1. .291
FT   CDS             292. .6141
FT                   /db_xref="GOA:Q8UZB6"
FT                   /db_xref="InterPro:IPR000606"
FT                   /db_xref="InterPro:IPR001788"
FT                   /db_xref="InterPro:IPR007094"
FT                   /db_xref="InterPro:IPR007095"
FT                   /db_xref="InterPro:IPR008043"
FT                   /db_xref="UniProt/TrEMBL:Q8UZB6"
FT                   /gene="REP"
FT                   /product="replicase"
FT                   /protein_id="CAC84400.1"
FT                   /translation="MVLTLCFHSDRDHHFLSTLPLAEIRRLAPGGFSVFVPEDLLPHLS
FT                   PSPSCPTPPLPRELTWSAACNPTNFPHLFRHHRPPPPCTRLTPRPPPPTPAPPSASTLP
FT                   RVFHGGAPPAAFQPAIDFLHNTIQKDTIASSIIAALNPSLTSSLTLYPYALPPRWPSAL
FT                   NQAGIPATSYGHQSHPHPIHKTIETHLLHEHWANRATLPSTVMFMKRSKFDKLRVSNAA
FT                   LVKSASNFLHLLNPILTARDADRYTHLPLPDTLPSTPLYFMHHSLMYFSPSQIAGLFLA
FT                   APFLERLYASLVLPAESTIGSHPFFPSLYRYRTTGEHLHYVLEGNPSSSYTQPLTATQW
FT                   LTTSSITAGDLHLTVTVLESWFSVHSILITRGVRPLELPRDIISLPSPDAVLLPNPSAF
FT                   DIPLRSRLVPRDVCESLFVYVRAVRTLRTTDPAGFIRTQSNKAEFDWVTAEAWDHLAQF
FT                   ALLTAPVRPNTYFLPLLSPLAVVRHWLFRKQRPIFATLTLLSASTAAAIPIAIARLRTH
FT                   SVTQLTILGHHFTPPKILARLPVALKRLIPKRLLPHLPSHLRPPPSWSPVFTLTFSELP
FT                   KARFLTFPISGQTHTLLRQLHVPAILFAPQRPSRPLIFAGLLIGTVPVLYGAYRWFVSR
FT                   FDPQTVYNRYSDLLHRPTWHLTFEREPLSCFPTPFLPHPSSHPRRARRLPPLPPAPPLP
FT                   PQPPPPPPPQPSPHPPLFPASIPSPPPRPSSPPPPATSPASTPALTPIPAPKTAPPLTF
FT                   PSPTLVAEPDAPVTARPSPLPLAPSRPFSELYPGHYADHSGSFFLQQPLVASSVPYPAL
FT                   DCLLVSCSAASGIPKEDLWATLCHIFPPSDLVSDLGLSTNHLTALAFTYQWLVTLRSGE
FT                   LVQRHGLLSAPFAFEITHTPPVPPATVGHFALSAPLTPTSACLTGGAPSPVISGPKASA
FT                   SLPRARFGPRPEAPRPPLTPPGFTPITEPTPATSPFALAALRFRLNRQPLPIRQVHAYS
FT                   IALPRAKNLVSNLKNGFDGLVSSLPASDRTNLLPLIQALDHTADFPPARPPVGLIHIAG
FT                   FAGCGKSYPIQQLLATQTFRHFRVVTPTTELRHEWKRALKLEGPSSWRVSTWETALAKR
FT                   ASVLVIDEVYKLPRGYLDLALLADPTVEFVIILGDPLQGSYNPTNPDSSNHRLIPEEDH
FT                   LRPFIDFYCLWTRRLPRLVADFFGVPTTNPTRGHLAFASLNTTQSPLLVPSDSMARALT
FT                   AGGHRAITYAASQGSTYPAPVHIFLDRNSNLVTNHVALVALTRSRSGVHFRPRAQDLPR
FT                   HPQHLFTAFYKYAIDLLAHEADPSKPRPTPVDVTLLFQQQLRGLTILRDPSFSRITGGA
FT                   THAFLAHAPLFTNLHGLRPTTFPDNLPTAPTYLARSLPYHQTESYPTSALPHRVFPAST
FT                   TDWSAADDHPRVNPTFVAETRLPLQSELAPTLPSQPEPSPTYHSPATFETVYPGVDGEA
FT                   LARTFLAATDPLELEIFFRNNWSNQFPFINRPDTVACNPLTLVAPTHNQKQDPTLLHAS
FT                   LAKRLRFRDSTAPYTITAKDQALGYILYHSLQRAYCRSPEPVPFDPVLFASCIAENDFA
FT                   QLTSKTQATIQANAFRSDPDWRHTFVRIFSKTQHKVNENSLFTSWKACQTLALMHDYLI
FT                   LVLGPVKKYQRILDSRDRPAHLYIHAGQTPHQLSEWCQNHLTPSVHLANDYTAFDQSQH
FT                   GEAVVLEAWKMRRASIPEPFITLHVHVKTNIECQFGPLTCMRITGEPGTYDDNTDYNLA
FT                   ILYTQYLLHRTPVLVSGDDSLVDRVPPMNPSWPALAPLFALKPKPETSPFGLFCGYFVG
FT                   PAGAVRAPRALFAKLAIALEDGSLPEKIASYVAEFSVGQSLGDSLWSLIPPELVIYQSA
FT                   CFDLICRHASPQLKLALRLGEVPDWGSLLSQLKLRFLTRPLFALLDAHTRVMVRTHKAH
FT                   LLPSGHALHPSTEPFY"
FT   CDS             6367. .7059
FT                   /db_xref="GOA:Q8UZB5"
FT                   /db_xref="HSSP:1DDL"
FT                   /db_xref="InterPro:IPR000574"
FT                   /db_xref="UniProt/TrEMBL:Q8UZB5"
FT                   /gene="CP"
FT                   /product="coat protein"
FT                   /protein_id="CAC84401.1"
FT                   /translation="MSLPADLLLGAISSLLRNPPTSDAASPSADQPAVSSSRSDSRLVS
FT                   APLPAAPPAPTAIARNPRVSIHLPFQFLWYDITGTESSYTSLSIASRPEVVTVARPYRH
FT                   ARLTSLEAFVQPTASSATYPQTVDLCWTIDSVTPARSEILSVFGAQRIAWGSVHFSAPI
FT                   LLPAELSSLNPTIKDSVTYTDCPRLTCGFYRNDACVALGSSAPICGSILIRGVIECSAP
FT                   INRPTPSS"
FT   CDS             6590. .7519
FT                   /db_xref="GOA:Q8UZB4"
FT                   /db_xref="InterPro:IPR003882"
FT                   /db_xref="UniProt/TrEMBL:Q8UZB4"
FT                   /note="ORF3"
FT                   /product="hypothetical protein"
FT                   /function="unknown"
FT                   /protein_id="CAC84402.1"
FT                   /translation="MTSRAPSPPTPPCPSPPALKSSPSPVPTATPASPPLKPLSNPLPP
FT                   PPPTPRPSTSAGPSTPLPPPALRSSPSSALNASRGAPSTSPPPSSSPPSSPASTPPSRT
FT                   PSPTPTAPASPVASTAMTPASPSVPPPPSAAPSSSAALSSAPPPSTAPLPRHEPRPPPP
FT                   LPPPLQPPPGVRVPRSVAFPLPLARELPPLRLPPAPYLHPLLARLAPLRLRPPPDLPSP
FT                   PLSPPLSPPLSPISPLHAPAPPPHPDPVLLPALSLAISRAAPDLLRLLSLLSPPSLFLL
FT                   FTLLSIHFSPFPIFILLSLLLLLQFPRT"
FT   CDS             7056. .7529
FT                   /db_xref="UniProt/TrEMBL:Q8UZB3"
FT                   /note="ORF4"
FT                   /product="hypothetical protein"
FT                   /function="unknown"
FT                   /protein_id="CAC84403.1"
FT                   /translation="MNRGPPLRSRPPSSPPPASAFPGPSPFPSPSPANSLPSASPPPPT
FT                   CTPSSPVSRPFASARLRTSHPPRCPHRSAPPSAPSPPFTPPHPLPTPTPSSSPRSPWLS
FT                   LAPLPTSSASLASFPPPPSSFSSPSSPSTSPLSPSSSSFPSSSSFSFLVPSNS"
XX
SQ   Sequence 7564 BP; 1054 A; 3774 C; 1236 G; 1500 T; 0 other;

 AJ309022  Length: 7564  April 19, 2005 08:53  Type: N  Check: 1261  ..

       1  gcacattagt actgaccacc agcccgactt tgacgccacc ctgtccaagt
      51  ccggcccgtg ctcactcttt tgtttttctt tgttcttttc ccctgctccc
     101  acgttcgacg acctcgcggc cgtcctcctc gcttcgtgct ctgcatcctt
     151  taacttcctc cccctcttcc tcctcgccct ttcctttctc atccacctcc
     201  ctcccaacct ctcttcctcc cttcactctc ttcttcttgc ttttcccttt
     251  ctcttcttct ttcttcctcc tgctctcccc atcctcccgc catggtgctc
     301  acgctctgct tccactcgga ccgtgaccat cacttcctct ccaccctccc
     351  cctcgccgag atcagacgtc tcgcgccagg cggcttctcc gtcttcgtcc
     401  ctgaagacct cctcccccac ctctccccct ccccctcctg ccccaccccc
     451  ccccttcccc gcgagctcac ctggagcgcc gcttgcaacc ccaccaactt
     501  cccccatctc tttcgccacc accgcccacc ccccccctgc acccgcctta
     551  ccccccgccc cccccccccc actcctgccc ctccctcagc ctccaccttg
     601  ccccgtgtct tccacggcgg cgccccccca gccgccttcc aacccgcgat
     651  cgacttcctt cacaacacaa tccagaagga tacgatcgcc tcctccatca
     701  ttgccgccct caacccttcc ctcacctcct ccctcaccct ctacccctac
     751  gcgctccccc cgcgctggcc ctccgccctc aaccaagccg gcatccccgc
     801  cacttcctac ggccaccaat cccaccccca cccaatccac aagaccattg
     851  aaacccatct cctccatgag cattgggcca accgtgcgac tctcccgtcc
     901  acggtcatgt tcatgaagag gtcgaagttc gacaagctcc gcgtctccaa
     951  cgcggctctc gtcaaatcgg cctcaaactt cctccacctc ctcaacccca
    1001  tcctcaccgc ccgggacgcc gaccggtaca cccacctccc cctccccgac
    1051  accctcccct ccacccctct ctacttcatg catcattccc tcatgtactt
    1101  ctcgcccagc caaattgccg ggctcttcct cgccgccccc ttcctcgaga
    1151  ggctctacgc ctctctcgtc ctcccggccg aatccaccat cggcagccac
    1201  cccttcttcc cctctctgta ccgctaccgc accaccggcg agcacctcca
    1251  ttacgtgctc gaaggcaacc catcctcctc ctacacccag cccctcaccg
    1301  ccacccagtg gctcaccacc tcctccatca ccgccggcga cctccacctc
    1351  accgtcaccg tcctcgagtc atggttctcc gtgcactcaa tcctcatcac
    1401  ccgcggtgtt cgccccctcg agctgccccg cgacatcatc tccctgccct
    1451  cccccgacgc cgtcctcctc cccaacccct ctgccttcga catccccctc
    1501  cgctcccggc tcgttccccg cgacgtctgc gaatcgctct tcgtttacgt
    1551  ccgcgccgtc cgtaccctcc gcaccaccga ccccgccggc ttcattcgaa
    1601  cccagtccaa caaggctgag ttcgactggg tcaccgccga ggcctgggac
    1651  cacctcgccc agttcgccct cctaaccgcc cccgtccgcc ccaacaccta
    1701  cttccttcct ctcctctccc cgctcgccgt cgtccgccat tggctctttc
    1751  gcaagcaaag gccaatcttc gccaccctca ccctcctctc cgcgtcaacc
    1801  gccgccgcca tccccatcgc catcgcccgc ctccgcaccc attcggtcac
    1851  ccagctcacc atcctcggcc accatttcac cccccccaag atcctcgctc
    1901  gccttcccgt cgccctcaag cgcttaatcc caaagcgcct gctcccccac
    1951  ctcccatccc acctccgccc ccccccttcc tggtccccgg tcttcaccct
    2001  caccttctcc gagctcccca aagcccggtt cctcaccttc cccatctccg
    2051  gccaaaccca caccctcctc cgacagctcc atgtccctgc catcctcttc
    2101  gccccccaac gccccagccg ccccctcatc ttcgcgggcc tgctcattgg
    2151  gactgtccct gttctgtacg gggcctaccg atggttcgtc tcccgcttcg
    2201  acccccagac ggtgtacaac cgttactctg accttcttca ccgccccaca
    2251  tggcacctca ccttcgagcg tgagcccctc agctgcttcc caaccccctt
    2301  tctgccccac cccagctccc accccagacg agcgcgtcgg ctcccccccc
    2351  tcccgcccgc cccacccctt ccaccccagc cgccaccgcc cccccccccc
    2401  caaccatccc cacacccccc cctcttcccc gcttcaatcc cgtcgcctcc
    2451  gccccgcccg tcctcaccgc ccccccccgc cacctccccc gcctccaccc
    2501  cggccctcac tcccatcccg gcgccgaaga ccgccccacc ccttaccttc
    2551  ccctccccca ccctcgtcgc tgagcccgac gcccccgtca ccgcccgccc
    2601  cagtcctctt cccctcgccc ccagccgccc cttctccgag ctctaccccg
    2651  gccactacgc cgatcattca ggctccttct tcctccagca gcccctcgtc
    2701  gcctcctccg tcccctaccc cgccctcgac tgccttctgg tctcctgctc
    2751  cgctgccagc ggaatcccaa aggaagacct ctgggccacc ctttgccaca
    2801  tctttccccc cagtgatctc gtctccgacc ttggcctctc caccaaccat
    2851  ctcaccgccc tcgccttcac ctaccagtgg ctggtcactc tccgctcagg
    2901  agagttggtc cagcgccacg gcctcctctc cgcccctttc gcctttgaga
    2951  tcacccacac cccacccgtt cctcccgcca ccgtcgggca cttcgccctc
    3001  tccgcccccc tcacccccac ctccgcttgc ctcaccgggg gcgccccttc
    3051  cccagtcatc tccggcccca aggcctccgc ctccctcccc cgcgcccgct
    3101  ttgggcctcg ccctgaagct ccccggcctc ccctgacccc ccctggcttc
    3151  actcccatca ccgagcccac ccctgccaca tccccgttcg ccctcgccgc
    3201  cctccgcttc cggctcaacc gccagcccct cccgatccgc caagtccacg
    3251  cctactccat cgccctccct cgcgccaaaa acctcgtctc caatctcaag
    3301  aacggattcg acggtctcgt ctcctccctc cccgcctccg accgcaccaa
    3351  cctcctcccc ctcatccaag cccttgatca caccgccgac ttccctcccg
    3401  cccgcccccc cgtcggcctc atccacatcg ccggcttcgc tggctgcggt
    3451  aagagctacc ccatccagca actgctcgcc acccagacct tccgccactt
    3501  ccgcgtcgtc acccccacca ctgagcttcg ccacgaatgg aaacgtgcgc
    3551  tcaagctcga aggcccctcc tcttggcgcg tctccacctg ggagacagcc
    3601  ctcgcgaagc gtgcttcggt ccttgtcatc gacgaggtct acaagctccc
    3651  tcgcgggtac ctcgaccttg cccttctcgc cgaccccacc gtcgagttcg
    3701  tcatcatcct cggcgacccc ctccaaggat cctacaaccc caccaacccc
    3751  gactcttcca accaccgcct catccccgaa gaagaccacc tccgcccgtt
    3801  catcgacttc tattgtctgt ggactcgccg cctcccccgc ctcgtcgccg
    3851  acttcttcgg cgtacccacc accaacccca ctcgcggtca cctcgccttc
    3901  gcctccctca acaccactca atcccctctc ctcgtcccct ccgactccat
    3951  ggcccgagcc ctcactgctg gcggccaccg cgccatcacc tacgccgcct
    4001  cccaaggttc cacttacccc gcccccgtcc acatcttcct tgaccgcaat
    4051  tctaacctcg tcaccaacca tgtcgccctc gtcgccctta cccgttcccg
    4101  ctctggcgtc cacttccgcc cccgcgccca ggacctccct cgccaccccc
    4151  agcacctctt caccgcgttc tacaagtacg cgatcgacct cctcgcccac
    4201  gaagccgatc cctccaagcc ccgccccacc cccgtcgacg tcacgctgct
    4251  cttccaacag cagctccgcg gcctcaccat cctccgtgac ccctccttct
    4301  cccgcatcac cggtggcgcc acccacgcct tcctcgccca cgccccactc
    4351  ttcaccaacc tccacggcct ccgccccacc accttcccgg acaaccttcc
    4401  caccgccccc acctacctgg cccgttccct cccctaccac cagaccgagt
    4451  cctaccccac ctcagccctc ccgcaccgtg tcttccccgc ctccaccacc
    4501  gactggtcag ccgccgacga ccatccccga gtcaacccca ccttcgtcgc
    4551  cgagacccgc ctccccctcc agagtgaact cgcccccacc ctcccatccc
    4601  aaccagaacc ttccccgacc taccactccc ccgccacctt cgagaccgtc
    4651  taccctggag tggacggcga agccctcgcc cgcaccttcc ttgccgccac
    4701  cgacccgttg gagctggaga tcttcttccg caacaactgg tccaaccagt
    4751  tccccttcat caaccgcccc gacaccgtag cctgcaaccc tctcaccctc
    4801  gtcgccccca cccacaacca aaagcaagac cccaccctcc tccacgcttc
    4851  cctcgccaag cgtctccgct tccgcgactc cacagccccc tacaccatca
    4901  ccgccaagga tcaagcctta ggctacatcc tttaccactc cctccagcgc
    4951  gcctactgcc gttcccccga gcccgtcccc ttcgacccag tcctcttcgc
    5001  gtcctgcatc gcggagaacg acttcgccca gctcacctcc aaaacccaag
    5051  ccaccatcca agccaacgcc ttccgctccg acccggattg gcgtcacacc
    5101  ttcgtccgca tcttctcgaa gacccagcac aaggtcaacg agaactctct
    5151  tttcacctct tggaaagcct gccagaccct cgccctcatg catgattact
    5201  tgatcctggt cctcggccca gtgaaaaagt atcagcgcat cctcgacagc
    5251  cgagaccgcc ccgcccatct ctacatccac gccggccaga ccccccacca
    5301  actttccgag tggtgccaaa accacctcac tccctccgtc cacctcgcca
    5351  atgactacac ggccttcgac caatcgcagc acggtgaagc cgtcgtgctc
    5401  gaggcttgga agatgcgccg cgcctccatt cctgaacctt tcatcaccct
    5451  ccacgtccac gtgaagacca acatcgaatg ccaatttggc cctctcacgt
    5501  gcatgcgcat caccggtgaa ccaggcacct acgacgacaa caccgactac
    5551  aacctggcca tcctctacac ccagtacctc ctccaccgca cccccgtcct
    5601  tgtgtccggc gatgactccc tcgtcgaccg cgtccccccc atgaaccctt
    5651  cttggcctgc cctcgccccc ctcttcgccc tcaagcccaa acccgagacc
    5701  tcccccttcg gccttttctg cggttacttc gtcggccccg ccggcgccgt
    5751  ccgcgccccc cgcgcccttt tcgccaagct cgcgatcgcc ctcgaggacg
    5801  gctctctgcc cgagaaaata gcgtcttacg tcgctgagtt ctcggtcggt
    5851  cagtccctcg gcgactccct ttggtccctc atcccccctg aactggtcat
    5901  ctaccagtca gcctgctttg acctcatctg ccgccacgcc tctccccagc
    5951  taaagctcgc cctccgtctc ggtgaggtcc ccgactgggg gtctctcctc
    6001  tcccagctca agctccgctt cctcacccgc cccctcttcg ccctcctcga
    6051  cgctcacact cgcgtcatgg tccgcaccca caaggctcac ctcctcccct
    6101  ccggccacgc cctccacccc tccaccgagc cattctacta gcctacttgc
    6151  gtgttgttgt tccaatgaca ccacgtcgcc cctcctcgcc atcctcgtcc
    6201  ttctcatcgt cgttctagcc tcagccctct tctgcgccct cttcgccctc
    6251  taccgtgtcg ccatccacca gaccgtcctc tcctccccgt ccttcgctcc
    6301  cccctccccc gtcccgctct agcatccccc ccctccgcat ccccaagccc
    6351  ctctccgcct cgtctgatga gcctccccgc tgacctcctc cttggcgcca
    6401  tctcctccct cctccgcaat ccccccacgt ctgatgccgc ctctccgtct
    6451  gctgaccagc ctgctgtctc tagctctcgc tctgactctc gcttggtcag
    6501  cgctccgctc cctgctgcgc cacccgcccc gaccgctatt gcccgcaacc
    6551  ctcgtgtaag catccatctc cccttccagt tcctgtggta tgacatcacg
    6601  ggcaccgagt cctcctacac ctccctgtcc atcgcctccc gccctgaagt
    6651  cgtcaccgtc gcccgtccct accgccacgc ccgcctcacc tcccttgaag
    6701  cctttgtcca acccactgcc tcctccgcca cctaccccca gaccgtcgac
    6751  ctctgctgga ccatcgactc cgttaccccc gcccgctctg agatcctctc
    6801  cgtcttcggc gctcaacgca tcgcgtgggg ctccgtccac ttctccgccc
    6851  ccatcctcct ccccgccgag ctctccagcc tcaaccccac catcaaggac
    6901  tccgtcacct acaccgactg cccccgcctc acctgtggct tctaccgcaa
    6951  tgacgcctgc gtcgccctcg gttcctccgc ccccatctgc ggctccatcc
    7001  tcatccgcgg cgttatcgag tgctccgccc ccatcaaccg ccccactccc
    7051  tcgtcatgaa ccgaggcccc cccctccgct cccgcccccc ctccagcccc
    7101  cccccggcgt ccgcgttccc cggtccgtcg cctttcccct ccccctcgcc
    7151  cgcgaactcc ctcccctccg cctccccccc gccccctacc tgcaccccct
    7201  cctcgcccgt ctcgcgcccc ttcgcctccg cccgcctccg gacctcccat
    7251  cccccccgct gtccccaccg ctcagccccc ccctcagccc catctccccc
    7301  cttcacgccc ccgcaccccc tccccacccc gaccccgtcc tcctccccgc
    7351  gctctccctg gctatctctc gcgccgctcc cgacctcctc cgcctcctta
    7401  gcctcctttc ccccccctcc ctcttccttc tcttcaccct cctctccatc
    7451  cacttctccc ctttccccat cttcatcctc ctttccctcc tcctcctcct
    7501  tcagtttcct cgtacctagc aatagctaga ggtagccggt ttctcactcc
    7551  ggcctttctt tctg