Notes on Genus: Thogotovirus

enveloped spheres or pleomorphic

Type member: Thogoto virus

Contents

• Members of this Genus
• General Description
• Morphology
• Electron Micrograph
• Genome
• Genus Genomic Organization
• Genome Map
• Type Member Genomic Organization
• All Known Sequences
• Curated Sequences

General Description

The genus Thogotovirus is one of the genera in the family Orthomyxoviridae. It is named from the type member. The viruses differ from those in most other genera of the family in having insect (tick) vectors and 6 or 7 apparently monocistronic genome segments. Distantly related tick-borne viruses are classifed in the genus Quaranjavirus.

Morphology

Virions spherical or pleomorphic, enveloped, 80-120 nm in diameter, with projections 4-6 nm in diameter and 10-14 nm long.

Genome

Single-stranded negative sense RNA in 6 or 7 segments totalling about 10.5 kb. The segments do not have a genome-linked protein (VPg) at their 5'-terminus nor a 3'-polyA tail.

Genus Genomic Organization

There are 6 or 7 RNA segments, most of which encode a single protein.

Type Member Genomic Organization

There are 6 RNA segments:

• RNA1 (2368 nts) encodes a basic polymerase (PB2) of 88.0 kDa
• RNA2 (2396 nts) encodes a basic polymerase (PB1) of 81.3 kDa
• RNA3 (2308 nts) encodes an acid polymerase (PA) of 71.4 kDa
• RNA4 (1882 nts) encodes a glycoprotein (G) of 57.5 kDa
• RNA5 (1841 nts) encodes the coat protein (Nucleoprotein, NP) of 51.8 kDa
• RNA6 (955 nts) encodes a matrix protein (M) of 29.8 kDa and an interferon antagonist (ML) of 34.4 kDa